Role of diuretics, β blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study
Identifieur interne : 004893 ( Main/Exploration ); précédent : 004892; suivant : 004894Role of diuretics, β blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study
Auteurs : Lan Shen [États-Unis, République populaire de Chine] ; Bimal R. Shah [États-Unis] ; Eric M. Reyes [États-Unis] ; Laine Thomas [États-Unis] ; Daniel Wojdyla [États-Unis] ; Peter Diem [Suisse, États-Unis] ; Lawrence A. Leiter [Canada, États-Unis] ; Bernard Charbonnel [France, États-Unis] ; Viacheslav Mareev [Russie, États-Unis] ; Edward S. Horton [États-Unis] ; Steven M. Haffner [Royaume-Uni, États-Unis] ; Vladimir Soska [République tchèque, États-Unis] ; Rury Holman [Royaume-Uni, États-Unis] ; M Angelyn Bethel [Royaume-Uni, États-Unis] ; Frank Schaper [Allemagne, États-Unis] ; Jie-Lena Sun [États-Unis] ; John Jv Mcmurray [Royaume-Uni, États-Unis] ; Robert M. Califf [États-Unis] ; Henry Krum [Australie, États-Unis]Source :
- BMJ : British Medical Journal [ 0959-8138 ] ; 2013-12-09.
Descripteurs français
- Wicri :
- topic : Collecte de données, Diabète, Glucose.
English descriptors
- KwdEn :
- Antihypertensive, Baseline, Baseline characteristics, Baseline variables, Blocker, Calcium channel blocker, Calcium channel blockers, Cardiovascular, Cardiovascular events, Cardiovascular morbidity, Cardiovascular outcomes, Confidence interval, Confounders, Covariate, Data analysis, Data collection, Data interpretation, December, Diabetes, Diabetes mellitus, Diuretic, Endpoint, Extreme weights, Fasting, Glucose, Glucose tolerance, Glucose tolerance outcomes research, Hazard ratio, Heart attack trial, High risk, High risk patients, High risk population, Hypertension, Inverse probability, Lancet, Manuscript review, Mellitus, Model hazard ratio, Navigator, Navigator trial, Novartis, Onset diabetes, Oral glucose tolerance test, Other studies, Previous studies, Randomised, Randomised trial, Reprint, Research institute, Research support, Risk factors, Serial glucose measurements, Statin, Statin therapy, Study design, Treatment initiation, Treatment patients, Treatment weighting.
- Teeft :
- Antihypertensive, Baseline, Baseline characteristics, Baseline variables, Blocker, Calcium channel blocker, Calcium channel blockers, Cardiovascular, Cardiovascular events, Cardiovascular morbidity, Cardiovascular outcomes, Confidence interval, Confounders, Covariate, Data analysis, Data collection, Data interpretation, December, Diabetes, Diabetes mellitus, Diuretic, Endpoint, Extreme weights, Fasting, Glucose, Glucose tolerance, Glucose tolerance outcomes research, Hazard ratio, Heart attack trial, High risk, High risk patients, High risk population, Hypertension, Inverse probability, Lancet, Manuscript review, Mellitus, Model hazard ratio, Navigator, Navigator trial, Novartis, Onset diabetes, Oral glucose tolerance test, Other studies, Previous studies, Randomised, Randomised trial, Reprint, Research institute, Research support, Risk factors, Serial glucose measurements, Statin, Statin therapy, Study design, Treatment initiation, Treatment patients, Treatment weighting.
Abstract
Objective To examine the degree to which use of β blockers, statins, and diuretics in patients with impaired glucose tolerance and other cardiovascular risk factors is associated with new onset diabetes. Design Reanalysis of data from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial. Setting NAVIGATOR trial. Participants Patients who at baseline (enrolment) were treatment naïve to β blockers (n=5640), diuretics (n=6346), statins (n=6146), and calcium channel blockers (n=6294). Use of calcium channel blocker was used as a metabolically neutral control. Main outcome measures Development of new onset diabetes diagnosed by standard plasma glucose level in all participants and confirmed with glucose tolerance testing within 12 weeks after the increased glucose value was recorded. The relation between each treatment and new onset diabetes was evaluated using marginal structural models for causal inference, to account for time dependent confounding in treatment assignment. Results During the median five years of follow-up, β blockers were started in 915 (16.2%) patients, diuretics in 1316 (20.7%), statins in 1353 (22.0%), and calcium channel blockers in 1171 (18.6%). After adjusting for baseline characteristics and time varying confounders, diuretics and statins were both associated with an increased risk of new onset diabetes (hazard ratio 1.23, 95% confidence interval 1.06 to 1.44, and 1.32, 1.14 to 1.48, respectively), whereas β blockers and calcium channel blockers were not associated with new onset diabetes (1.10, 0.92 to 1.31, and 0.95, 0.79 to 1.13, respectively). Conclusions Among people with impaired glucose tolerance and other cardiovascular risk factors and with serial glucose measurements, diuretics and statins were associated with an increased risk of new onset diabetes, whereas the effect of β blockers was non-significant. Trial registration ClinicalTrials.gov NCT00097786.
Url:
- https://api.istex.fr/document/3FBB3288FDB8558B560FAFE3A176244F8342DB67/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898638
DOI: 10.1136/bmj.f6745
Affiliations:
- Allemagne, Australie, Canada, France, Royaume-Uni, Russie, République populaire de Chine, République tchèque, Suisse, États-Unis
- Angleterre, Canton de Berne, Caroline du Nord, District de Dresde, District fédéral central, Massachusetts, Moravie, Oxfordshire, Pays de la Loire, Saxe (Land), Écosse
- Berne, Brno, Dresde, Glasgow, Moscou, Nantes, Oxford
- Université d'Oxford, Université de Berne, Université de Glasgow
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Horton</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Joslin Diabetes Center, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Haffner, Steven M" sort="Haffner, Steven M" uniqKey="Haffner S" first="Steven M" last="Haffner">Steven M. Haffner</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Soska, Vladimir" sort="Soska, Vladimir" uniqKey="Soska V" first="Vladimir" last="Soska">Vladimir Soska</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>2nd Clinic of Internal Medicine and Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Holman, Rury" sort="Holman, Rury" uniqKey="Holman R" first="Rury" last="Holman">Rury Holman</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Churchill Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Bethel, M Angelyn" sort="Bethel, M Angelyn" uniqKey="Bethel M" first="M Angelyn" last="Bethel">M Angelyn Bethel</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Schaper, Frank" sort="Schaper, Frank" uniqKey="Schaper F" first="Frank" last="Schaper">Frank Schaper</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Clinical Studies, Metabolism and Endocrinology Knowledge and Technology Transfer of Dresden University of Technology, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Sun, Jie Lena" sort="Sun, Jie Lena" uniqKey="Sun J" first="Jie-Lena" last="Sun">Jie-Lena Sun</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Clinical Research Institute, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Mcmurray, John Jv" sort="Mcmurray, John Jv" uniqKey="Mcmurray J" first="John Jv" last="Mcmurray">John Jv Mcmurray</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>British Heart Foundation Cardiovascular Research Centre, University of Glasgow</wicri:regionArea><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université de Glasgow</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Califf, Robert M" sort="Califf, Robert M" uniqKey="Califf R" first="Robert M" last="Califf">Robert M. Califf</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Clinical Research Institute, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Krum, Henry" sort="Krum, Henry" uniqKey="Krum H" first="Henry" last="Krum">Henry Krum</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Centre of Cardiovascular Research and Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University/Alfred Hospital, Melbourne VIC 3004</wicri:regionArea><wicri:noRegion>Melbourne VIC 3004</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">BMJ : British Medical Journal</title><title level="j" type="abbrev">BMJ</title><idno type="ISSN">0959-8138</idno><idno type="eISSN">1756-1833</idno><imprint><publisher>British Medical Journal Publishing Group</publisher><date type="published" when="2013-12-09">2013-12-09</date><biblScope unit="volume">347</biblScope></imprint><idno type="ISSN">0959-8138</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-8138</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antihypertensive</term><term>Baseline</term><term>Baseline characteristics</term><term>Baseline variables</term><term>Blocker</term><term>Calcium channel blocker</term><term>Calcium channel blockers</term><term>Cardiovascular</term><term>Cardiovascular events</term><term>Cardiovascular morbidity</term><term>Cardiovascular outcomes</term><term>Confidence interval</term><term>Confounders</term><term>Covariate</term><term>Data analysis</term><term>Data collection</term><term>Data interpretation</term><term>December</term><term>Diabetes</term><term>Diabetes mellitus</term><term>Diuretic</term><term>Endpoint</term><term>Extreme weights</term><term>Fasting</term><term>Glucose</term><term>Glucose tolerance</term><term>Glucose tolerance outcomes research</term><term>Hazard ratio</term><term>Heart attack trial</term><term>High risk</term><term>High risk patients</term><term>High risk population</term><term>Hypertension</term><term>Inverse probability</term><term>Lancet</term><term>Manuscript review</term><term>Mellitus</term><term>Model hazard ratio</term><term>Navigator</term><term>Navigator trial</term><term>Novartis</term><term>Onset diabetes</term><term>Oral glucose tolerance test</term><term>Other studies</term><term>Previous studies</term><term>Randomised</term><term>Randomised trial</term><term>Reprint</term><term>Research institute</term><term>Research support</term><term>Risk factors</term><term>Serial glucose measurements</term><term>Statin</term><term>Statin therapy</term><term>Study design</term><term>Treatment initiation</term><term>Treatment patients</term><term>Treatment weighting</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Antihypertensive</term><term>Baseline</term><term>Baseline characteristics</term><term>Baseline variables</term><term>Blocker</term><term>Calcium channel blocker</term><term>Calcium channel blockers</term><term>Cardiovascular</term><term>Cardiovascular events</term><term>Cardiovascular morbidity</term><term>Cardiovascular outcomes</term><term>Confidence interval</term><term>Confounders</term><term>Covariate</term><term>Data analysis</term><term>Data collection</term><term>Data interpretation</term><term>December</term><term>Diabetes</term><term>Diabetes mellitus</term><term>Diuretic</term><term>Endpoint</term><term>Extreme weights</term><term>Fasting</term><term>Glucose</term><term>Glucose tolerance</term><term>Glucose tolerance outcomes research</term><term>Hazard ratio</term><term>Heart attack trial</term><term>High risk</term><term>High risk patients</term><term>High risk population</term><term>Hypertension</term><term>Inverse probability</term><term>Lancet</term><term>Manuscript review</term><term>Mellitus</term><term>Model hazard ratio</term><term>Navigator</term><term>Navigator trial</term><term>Novartis</term><term>Onset diabetes</term><term>Oral glucose tolerance test</term><term>Other studies</term><term>Previous studies</term><term>Randomised</term><term>Randomised trial</term><term>Reprint</term><term>Research institute</term><term>Research support</term><term>Risk factors</term><term>Serial glucose measurements</term><term>Statin</term><term>Statin therapy</term><term>Study design</term><term>Treatment initiation</term><term>Treatment patients</term><term>Treatment weighting</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Collecte de données</term><term>Diabète</term><term>Glucose</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objective To examine the degree to which use of β blockers, statins, and diuretics in patients with impaired glucose tolerance and other cardiovascular risk factors is associated with new onset diabetes. Design Reanalysis of data from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial. Setting NAVIGATOR trial. Participants Patients who at baseline (enrolment) were treatment naïve to β blockers (n=5640), diuretics (n=6346), statins (n=6146), and calcium channel blockers (n=6294). Use of calcium channel blocker was used as a metabolically neutral control. Main outcome measures Development of new onset diabetes diagnosed by standard plasma glucose level in all participants and confirmed with glucose tolerance testing within 12 weeks after the increased glucose value was recorded. The relation between each treatment and new onset diabetes was evaluated using marginal structural models for causal inference, to account for time dependent confounding in treatment assignment. Results During the median five years of follow-up, β blockers were started in 915 (16.2%) patients, diuretics in 1316 (20.7%), statins in 1353 (22.0%), and calcium channel blockers in 1171 (18.6%). After adjusting for baseline characteristics and time varying confounders, diuretics and statins were both associated with an increased risk of new onset diabetes (hazard ratio 1.23, 95% confidence interval 1.06 to 1.44, and 1.32, 1.14 to 1.48, respectively), whereas β blockers and calcium channel blockers were not associated with new onset diabetes (1.10, 0.92 to 1.31, and 0.95, 0.79 to 1.13, respectively). Conclusions Among people with impaired glucose tolerance and other cardiovascular risk factors and with serial glucose measurements, diuretics and statins were associated with an increased risk of new onset diabetes, whereas the effect of β blockers was non-significant. Trial registration ClinicalTrials.gov NCT00097786.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Royaume-Uni</li><li>Russie</li><li>République populaire de Chine</li><li>République tchèque</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Canton de Berne</li><li>Caroline du Nord</li><li>District de Dresde</li><li>District fédéral central</li><li>Massachusetts</li><li>Moravie</li><li>Oxfordshire</li><li>Pays de la Loire</li><li>Saxe (Land)</li><li>Écosse</li></region><settlement><li>Berne</li><li>Brno</li><li>Dresde</li><li>Glasgow</li><li>Moscou</li><li>Nantes</li><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Berne</li><li>Université de Glasgow</li></orgName></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Shen, Lan" sort="Shen, Lan" uniqKey="Shen L" first="Lan" last="Shen">Lan Shen</name></region><name sortKey="Bethel, M Angelyn" sort="Bethel, M Angelyn" uniqKey="Bethel M" first="M Angelyn" last="Bethel">M Angelyn Bethel</name><name sortKey="Califf, Robert M" sort="Califf, Robert M" uniqKey="Califf R" first="Robert M" last="Califf">Robert M. Califf</name><name sortKey="Califf, Robert M" sort="Califf, Robert M" uniqKey="Califf R" first="Robert M" last="Califf">Robert M. Califf</name><name sortKey="Charbonnel, Bernard" sort="Charbonnel, Bernard" uniqKey="Charbonnel B" first="Bernard" last="Charbonnel">Bernard Charbonnel</name><name sortKey="Diem, Peter" sort="Diem, Peter" uniqKey="Diem P" first="Peter" last="Diem">Peter Diem</name><name sortKey="Haffner, Steven M" sort="Haffner, Steven M" uniqKey="Haffner S" first="Steven M" last="Haffner">Steven M. Haffner</name><name sortKey="Holman, Rury" sort="Holman, Rury" uniqKey="Holman R" first="Rury" last="Holman">Rury Holman</name><name sortKey="Horton, Edward S" sort="Horton, Edward S" uniqKey="Horton E" first="Edward S" last="Horton">Edward S. Horton</name><name sortKey="Horton, Edward S" sort="Horton, Edward S" uniqKey="Horton E" first="Edward S" last="Horton">Edward S. Horton</name><name sortKey="Krum, Henry" sort="Krum, Henry" uniqKey="Krum H" first="Henry" last="Krum">Henry Krum</name><name sortKey="Krum, Henry" sort="Krum, Henry" uniqKey="Krum H" first="Henry" last="Krum">Henry Krum</name><name sortKey="Leiter, Lawrence A" sort="Leiter, Lawrence A" uniqKey="Leiter L" first="Lawrence A" last="Leiter">Lawrence A. Leiter</name><name sortKey="Mareev, Viacheslav" sort="Mareev, Viacheslav" uniqKey="Mareev V" first="Viacheslav" last="Mareev">Viacheslav Mareev</name><name sortKey="Mcmurray, John Jv" sort="Mcmurray, John Jv" uniqKey="Mcmurray J" first="John Jv" last="Mcmurray">John Jv Mcmurray</name><name sortKey="Reyes, Eric M" sort="Reyes, Eric M" uniqKey="Reyes E" first="Eric M" last="Reyes">Eric M. Reyes</name><name sortKey="Reyes, Eric M" sort="Reyes, Eric M" uniqKey="Reyes E" first="Eric M" last="Reyes">Eric M. Reyes</name><name sortKey="Schaper, Frank" sort="Schaper, Frank" uniqKey="Schaper F" first="Frank" last="Schaper">Frank Schaper</name><name sortKey="Shah, Bimal R" sort="Shah, Bimal R" uniqKey="Shah B" first="Bimal R" last="Shah">Bimal R. Shah</name><name sortKey="Shah, Bimal R" sort="Shah, Bimal R" uniqKey="Shah B" first="Bimal R" last="Shah">Bimal R. Shah</name><name sortKey="Shen, Lan" sort="Shen, Lan" uniqKey="Shen L" first="Lan" last="Shen">Lan Shen</name><name sortKey="Soska, Vladimir" sort="Soska, Vladimir" uniqKey="Soska V" first="Vladimir" last="Soska">Vladimir Soska</name><name sortKey="Sun, Jie Lena" sort="Sun, Jie Lena" uniqKey="Sun J" first="Jie-Lena" last="Sun">Jie-Lena Sun</name><name sortKey="Sun, Jie Lena" sort="Sun, Jie Lena" uniqKey="Sun J" first="Jie-Lena" last="Sun">Jie-Lena Sun</name><name sortKey="Thomas, Laine" sort="Thomas, Laine" uniqKey="Thomas L" first="Laine" last="Thomas">Laine Thomas</name><name sortKey="Thomas, Laine" sort="Thomas, Laine" uniqKey="Thomas L" first="Laine" last="Thomas">Laine Thomas</name><name sortKey="Wojdyla, Daniel" sort="Wojdyla, Daniel" uniqKey="Wojdyla D" first="Daniel" last="Wojdyla">Daniel Wojdyla</name><name sortKey="Wojdyla, Daniel" sort="Wojdyla, Daniel" uniqKey="Wojdyla D" first="Daniel" last="Wojdyla">Daniel Wojdyla</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Shen, Lan" sort="Shen, Lan" uniqKey="Shen L" first="Lan" last="Shen">Lan Shen</name></noRegion></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Diem, Peter" sort="Diem, Peter" uniqKey="Diem P" first="Peter" last="Diem">Peter Diem</name></region></country><country name="Canada"><noRegion><name sortKey="Leiter, Lawrence A" sort="Leiter, Lawrence A" uniqKey="Leiter L" first="Lawrence A" last="Leiter">Lawrence A. Leiter</name></noRegion></country><country name="France"><region name="Pays de la Loire"><name sortKey="Charbonnel, Bernard" sort="Charbonnel, Bernard" uniqKey="Charbonnel B" first="Bernard" last="Charbonnel">Bernard Charbonnel</name></region></country><country name="Russie"><region name="District fédéral central"><name sortKey="Mareev, Viacheslav" sort="Mareev, Viacheslav" uniqKey="Mareev V" first="Viacheslav" last="Mareev">Viacheslav Mareev</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Haffner, Steven M" sort="Haffner, Steven M" uniqKey="Haffner S" first="Steven M" last="Haffner">Steven M. Haffner</name></region><name sortKey="Bethel, M Angelyn" sort="Bethel, M Angelyn" uniqKey="Bethel M" first="M Angelyn" last="Bethel">M Angelyn Bethel</name><name sortKey="Holman, Rury" sort="Holman, Rury" uniqKey="Holman R" first="Rury" last="Holman">Rury Holman</name><name sortKey="Mcmurray, John Jv" sort="Mcmurray, John Jv" uniqKey="Mcmurray J" first="John Jv" last="Mcmurray">John Jv Mcmurray</name></country><country name="République tchèque"><region name="Moravie"><name sortKey="Soska, Vladimir" sort="Soska, Vladimir" uniqKey="Soska V" first="Vladimir" last="Soska">Vladimir Soska</name></region></country><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Schaper, Frank" sort="Schaper, Frank" uniqKey="Schaper F" first="Frank" last="Schaper">Frank Schaper</name></region></country><country name="Australie"><noRegion><name sortKey="Krum, Henry" sort="Krum, Henry" uniqKey="Krum H" first="Henry" last="Krum">Henry Krum</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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